Increased Bone Mass in Mice after Single Injection of Anti-receptor Activator of Nuclear Factor- B Ligand-neutralizing Antibody EVIDENCE FOR BONE ANABOLIC EFFECT OF PARATHYROID HORMONE IN MICE WITH FEW OSTEOCLASTS*□
نویسندگان
چکیده
Yuriko Furuya, Kaoru Mori, Tadashi Ninomiya, Yoshiya Tomimori, Sakae Tanaka, Naoyuki Takahashi, Nobuyuki Udagawa , Kohji Uchida, and Hisataka Yasuda** From the Nagahama Institute for Biochemical Science, Nagahama Branch, Oriental Yeast Co., Limited, 50 Kano-cho Nagahama, Shiga 526-0804, the **Bioindustry Division, Oriental Yeast Co., Limited, 3-610 Azusawa, Itabashi-ku, Tokyo 174-8505, the Institute for Oral Science and Department of Biochemistry, Matsumoto Dental University, 1780 Gobara, Hiro-oka, Shiojiri, Nagano 399-0781, and the Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
منابع مشابه
Increased Bone Mass in Mice after Single Injection of Anti-receptor Activator of Nuclear Factor-κB Ligand-neutralizing Antibody
Receptor activator of nuclear factor-κB ligand (RANKL) is a pivotal osteoclast differentiation factor. To investigate the effect of RANKL inhibition in normal mice, we prepared an anti-mouse RANKL-neutralizing monoclonal antibody (Mab, clone OYC1) and established a new mouse model with high bone mass induced by administration of OYC1. A single subcutaneous injection of 5 mg/kg OYC1 in normal mi...
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The clinical findings that alendronate blunted the anabolic effect of human parathyroid hormone (PTH) on bone formation suggest that active resorption is involved and enhances the anabolic effect. PTH signals via its receptor on the osteoblast membrane, and osteoclasts are impacted indirectly via the products of osteoblasts. Microarray with RNA from rats injected with human PTH or vehicle showe...
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Parathyroid hormone (PTH) exerts both catabolic and anabolic actions on bone. Studies on the skeletal effects of PTH have seldom considered the effects of gender. Our study was designed to determine whether the response of mouse bone to PTH differed according to sex. As a first step, we analyzed gender differences with respect to bone mass and structural properties of 4 month old PTH treated (8...
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